Malignancies and Complications (Videos Available)

Tuesday July 03, 2018 from 09:45 to 11:15

Room: N-101

415.6 Interventional radiology in complication management after pediatric liver transplantation (Video Available)

Artem Monakhov, Russian Federation

Federal State Budgetary Institution “Academician V.I.Shumakov Federal Research Center of Transplantology and Artificial Organs”

Abstract

Interventional Radiology in Complication Management after Pediatric Liver Transplantation

Artem Monakhov1,2, Boris Mironkov1, Olga Tsiroulnikova1,2, Mikhail Voskanov1,2, Timur Dzhanbekov1, Konstantin Semash1, Sergey Meshcheryakov1, Robert Latypov1, Veronika Pets1, Khizri Khizroev1, Sergey Gautier1,2.

1V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs, Moscow, Russian Federation; 2The First Moscow State Medical University (Sechenov University), Moscow, Russian Federation

Introduction:  Significant progress in percutaneous interventional correction of complications in children after liver transplantation was achieved during the period from May 2015 to October 2017. The method was established to be an effective technique of miniinvasive surgical care for children who developed complications after liver transplantation.
Object: To estimate surgical technique and results of percutaneous interventional correction of surgical complications after liver transplantation in pediatric patients.
Methods and Patients: 206 pediatric liver transplantations were performed during the observation period. 18 patients (10 boys and 8 girls) underwent correction of complications: 6 cases of arterial stenosis, 4 cases of the portal vein stenosis and 8 cases of biliodigestive anastomosis stricture.
The age of the patients was from 6 months to 14 years (7.5 years ± 7). The body weight of the children varied from 6 to 51 kg (28 kg ± 22).  Liver graft types were Left lateral segment in 15 cases (living related donor liver transplantation), Left lateral segment in 1 case and Right Lobe in 1 case (split-liver transplantation) and Whole Liver in 1 case.
Correction of arterial stenosis was managed by endovascular angioplasty in X-ray operating room: balloon vasodilation in 3 cases, balloon vasodilation and stenting in 3 cases. All patients after the intervention received continuous administration of heparin in an individual dose under the control of activated partial thromboplastin time every 6 hours.
Repair of the portal vein stenosis implied endovascular angioplasty: balloon vasodilation in 1 case, and stenting of the portal vein in 3 cases. All patients received oral antiplatelet therapy in the postoperative period.
Management of the biliary stricture included percutaneous transhepatic external-internal drainage of the biliary tree, followed by a programmed replacement of similar drains with larger diameter. A total of 35 procedures were performed during the observation period in 8 patients.
Results: The observation period was from 12 days to 2 years. All patients are alive, with a good function of the liver graft. In patients after correction of vascular complications, there was a stable positive dynamics of  Doppler carting - an increase of the laminar flow velocity of the portal vein and the artery of the graft up to normal values, a reduce of the cytolysis syndrome and in patients after biliary stricture correction, decrease of the cholestatic syndrome according to the biochemical blood test, a decrease in the diameter of the bile ducts of the graft according to ultrasound examination, regression of the clinical manifestations of cholangitis.
Conclusion: Percutaneous interventional correction of vascular and biliary complications after liver transplantation is a safe and effective technique for children, being minimally invasive, and avoiding traumatic reconstructive surgeries and providing normal liver function in a short time.



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