Kidney Posters

Tuesday July 03, 2018 from 16:30 to 17:30

Room: Hall 10 - Exhibition

P.060 Outcomes of kidney transplantation from expanded-criteria deceased donors in a single center

Roberto C Manfro, Brazil

Professor of Medicine
Nephrology and Transplantation
Federal University of Rio Grande do Sul

Abstract

Outcomes of Kidney Transplantation from Expanded-Criteria Deceased Donors in a Single Center

Adriana Ribeiro1, Alessandra R Viccari1, Priscila Prada1, Roberto C Manfro1,2.

1Transplant Department, Hospital de Clinicas de Porto Alegre, Pto Alegre, Brazil; 2Medicine School, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

Introduction: Expanded donors criteria(ECDs) are a source of kidneys that increase the donor organ pool.The value of transplanting these kidneys is uncertain in our population because of concerns regarding diminished survival and predicted poorer outcomes .Our objective was to compare long-term outcomes of kidney from ECDs with those concurrent standard-criteria donors (SCDs).
Materials and Methods: We retrospectively reviewed our single-center experience with ECD kidney transplants (KT). Between January 2009 and December 2015 we performed 701 KTs from deceased donor. These patients were divided according to donor status into  ECD ou SCD. Patients were followed untill 5 year after tansplantantation, death, graft failure, or loss to follow up. Results and Discussion: During the period of study 470 patients (67%) were transplanted with SCDs kidneys  and 231 (33%) with ECDs kidneys. Baselines characteristics (race, gender, cause of end stage renal disease, number of HLA antigen mismatches and imunossupression) were similar between the groups.  DGF incidence was higher in ECDs group (76% vs 64,7%, p=0.033) which determined prolonged hospilalization time (p<0.02).  Mean glomerular filtration rate was consistently lower in the ECD group  at 1 month ( 34.4 + 17.7 mL/min vs 45.5 + 24.3mL/min), 3 months (40.7 + 16.2mL/min vs 55.6 + 27.3mL/min), 6 months (40.6 + 16.1 mL/min vs 55.0 + 23.7mL/min) and 12 months after transplantation(44.3 + 18.3 mL/min vs 60.5 + 24.3mL/min); p <0.01. Patient and graft survivals rates were  between 2 groups. There were no significant differences at 1 year,  3 years and 5 years in graft survival (p=0,268)  and 1 year, 3 years and 5 years in patient survival  (p=0,264)
Conclusion: althoug renal function was better in SCD kidney recipientes, graft and patient survival of ECD kidney recipientes were comparable whith those of SCD kidney recipients. In conclusion, use of renal grafts from ECDs is a acceptable strategy for kidney transplantation.  



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