Kidney Posters

Monday July 02, 2018 from 16:30 to 17:30

Room: Hall 10 - Exhibition

P.111 Spot urinary sodium may be an indicator for high blood pressure and metabolic syndrome in kidney transplant recipients

Burak Sayin, Turkey

Asst. Prof. Dr.
Nephrology
Baskent University

Abstract

Spot Urinary Sodium May Be an Indicator for High Blood Pressure and Metabolic Syndrome in Kidney Transplant Recipients

Tugba Izci1, Burak Sayin2, Turan Colak2, Nurhan Ozdemir Acar2, Siren Sezer2, Mehmet Haberal3.

1Internal Medicine, Baskent University, Ankara, Turkey; 2Nephrology, Baskent University, Ankara, Turkey; 3Transplantation, Baskent University, Ankara, Turkey

Introduction: High sodium, a common problem in general population, is associated with high blood pressure and cardiovascular disorders. Kidney transplant recipients are particularly under risk for hypertension and metabolic syndrome. In our study, we aimed to determine the relationship between high sodium intake and metabolic disturbances in our KT recipients by measuring spot urinary sodium as an indicator of daily sodium intake.
Materials and Methods: 125 KT recipients being followed-up in our Transplantation Outpatient Clinic were enrolled in the study. Acute rejection episode in the last 12 months, chronic allograft dysfunction, pregnancy, diabetes mellitus, high-grade proteinuria were exclusion criteria. The demographics, office blood pressure, height, weight, BMI, waist and hip measurements, immune suppressive drugs, other medication and biochemical parameters of the patients were recorded. We also measured spot urinary sodium, spot urinary protein in the first morning urine in all the KT recipients.  
Results: 125 KT recipients (44 female, 81 male) with a mean age of 40.7 ± 12.0 were enrolled to our study. Metabolic syndrome was diagnosed in 85 patients (64.8%).  The biochemical parameters and anthropologic measures are summarized in Table-1.  Patients were divided into 2 groups according to the spot urinary sodium levels.
The lower urinary sodium group (Group 1) showed significantly higher eGFR  and HDL levels  compared to higher urinary sodium group (Group 2) whereas Group 2 patients showed significantly higher serum insulin levels, higher fasting glucose levels, higher  body mass index, higher waist to hip ratio, higher LDL, serum creatinine and BUN levels compared to Group 1.
Conclusion: Our study showed that spot urinary sodium excretion is a simple method to determine average daily sodium intake which is closely associated with high BP, high lipid profile, abdominal obesity and as well as metabolic syndrome in KT recipients. 

Biochemical Parameters & Anthropologic Measures (p<.05 is statistically significant)
  Group 1 (Low urinary sodium) Group 2 (High urinary sodium)

P value

Age(years) 40.8 ± 1.6 40.5 ± 12.5 0.88
Fasting Glucose(mg/dL) 101.3 ± 16.5 112 ± 14.7 0.01*
BUN(mg/dL) 18.4 ± 7.7 22.9 ±11.1  0.04*
Creatinine(mg/dL) 1.2 ± 0.5 1.5 ± 0.6 0.02*
Albumin(g/dL) 4.2 ± 0.3 4.1 ± 0.3 0.35
eGFR(mL/min) 65.5 ± 27.1 53.5 ± 18.5 0.03*
Spot urinary protein (mg) 33.4 ± 49.5 69.4 ± 97.8 0.03*
LDL (mg/dL) 128.1 ± 45.1 127.9 ± 38.5 0.07*
HDL (mg/dL) 51.5 ± 16.6 43.8 ± 11.4 0.04*
Triglyceride (mg/dL) 149.5 ± 60.1 194.4 ± 97.7 0.01*
Insulin (mcU/mL) 13.2 ± 5.2 18.1 ± 6.5 0.01*
Body Mass Index(kg/m²) 30.3 ± 11.2 25.7 ± 8.8 0.01*
Systolic blood pressure(mmHg) 122.2 ± 4.6 136.6 ± 13.9 0.02*
Diastolic blood pressure(mmHg) 57.5 ± 5.4 61.0 ± 3.3 0.01*



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