435.1 The development and function of Treg (Video Available)

Abul K Abbas, United States

Professor and Chair
Pathology
University of California San Francisco

Overview

The development and functions of regulatory T cells
Regulatory T cells (Treg) arise in the thymus upon recognition of self antigens and in peripheral tissues in response to self and foreign (e.g. graft and tumor) antigens. Treg suppress immune responses by multiple mechanisms, including interfering with costimulation and producing immunosuppressive cytokines. Treg are highly responsive to interleukin-2 (IL-2) and require IL-2 for their survival and function. This realization has led to ongoing therapeutic attempts to boost Treg by administration of IL-2 in forms that preferentially act on these cells.



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