Tuesday July 03, 2018 from 16:30 to 17:30
Propensity Score Matching Analysis of Post-Transplant Outcomes in Living Donor Liver Transplantation for Obese Recipients (BMI≥30)
Chan Woo Cho1, Kyeong Sik Kim1, Sang Jin Kim1, Gyu-Seong Choi1, Jong Man Kim1, Choon Hyuck D Kwon1, Jae-Won Joh1, Shin-Seok Yang2.
1Surgery, Samsung medical center, SEOUL, Korea; 2Surgery, Yeungnam University College of Medicine, Daegu, Korea
Although living donor liver transplantation (LDLT) for obese (O) recipients has increased, it is not been shown that post-transplant outcomes in O recipients are inferior compared to non-obese (NO) recipients. From January 2001 to December 2016 there was a total of 58 (6%) obese patients (BMI≥30) in a cohort of 973 adult patients that underwent LDLT. After propensity score matching, there were 58 patients in the O group (visceral fat obesity [VFO, N=45] and subcutaneous fat obesity [SFO, N=13]) and 141 in the NO group (non-visceral fat obesity [NVFO, N=107] and non-subcutaneous fat obesity [NSFO, N=34]). We performed comparative analysis of post-transplant outcomes. Early allograft dysfunction (EAD) was found in 11 (19%) and 31 (22%) patients in the O and NO groups, respectively (P=.705). The O group had a higher Model for Early Allograft Function (MEAF) score (5.2 versus 4.5, P=.007) than the NO group. In subgroup analysis of the VFO versus the NVFO subgroup or the SFO versus the NSFO subgroup, the MEAF score of the VFO was significantly higher than that of the NVFO (5.4 versus 4.6, P=.014). In conclusion, obesity, especially VFO, may impact the severity of EAD after LDLT.