Living Donation and Organ Utilization (Videos Available)

Wednesday July 04, 2018 from 17:15 to 18:45

Room: N-105

587.4 Risk factors for failure to complete post-donation follow-up among obese living kidney donors

Jayme E. Locke, United States

Assistant Professor of Surgery
Surgery / Transplantation
University of Alabama at Birmingham

Abstract

Risk Factors for Failure to Complete Post-Donation Follow-up Among Obese Living Kidney Donors

Rhiannon Reed1, Paul A MacLennan1, Brittany A Shelton1, Margaux N Mustian1, Deanna M McWilliams1, Deirdre Sawinski2, Jayme E Locke1.

1Surgery, University of Alabama at Birmingham, Birmingham, AL, United States; 2Medicine, University of Pennsylvania, Philadelphia, PA, United States

Introduction: Living kidney donors in the United States who were obese at the time of donation are at greater risk of end-stage renal disease than their non-obese counterparts, and may benefit from more intensive post-donation follow-up. Compared to their non-obese counterparts, obese living donors are less likely to have complete follow-up data. It is unknown what factors may be driving greater risk for incomplete follow-up among obese living donors.
Materials and Methods: Adult living kidney donors with obesity (body mass index ≥ 30 kg/m2) at donation and reported to the Scientific Registry of Transplant Recipients from January 2005-July 2015 were included (n=13,831). Donor characteristics were compared based on having a recorded serum creatinine at 6-months post-donation, and multilevel logistic regression models were used to estimate odds of 6-month creatinine measurement, with a random intercept for recovery center.
Results: Obese donors who were older, female, Caucasian, married, had a history of hypertension, and were insured at donation were more likely to have a 6-month serum creatinine recorded on unadjusted analyses; obese donors with less than a college education or those biologically related to their recipient were less likely to have a 6-month serum creatinine (Table 1). After adjustment, older age, female sex, and donation following the implementation of new center follow-up requirements were associated with higher odds of 6-month creatinine, while lower odds of 6-month creatinine were seen for biologically-related donors and donors at centers with higher total living donor volume (Table 2). 
Conclusion: Obese donors biologically related to their recipient or who donated at a high volume living donor center were less likely to have 6-month follow-up.  These findings suggest the need for targeted education and intervention both at the patient and center level to increase follow-up among obese living donors.



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